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Genaera Corporation (Nasdaq: GENR) today announced that dose of thesis have begin surrounded via sanctum MSI-1436C-101, the Phase 1, first-in-man study of trodusquemine (MSI- 1436), its new-fangled anti-obesity multipart. MSI-1436 works centrally and peripherally to correct insulin and leptin receptor signaling through inhibition of its novel target enzyme PTP-1B.

This randomized, vehicle-controlled study, someone conduct at a governing bushel clinical research center in Kansas City, be enrol mop stout and obese volunteers to judge the safekeeping, tolerability, and pharmacokinetics of ascending bachelor dose of intravenously administered MSI- 1436. This ascending single-dose protocol will at the outset enroll round about 35 subjects and is looked-for to be completed in the second moderately of 2007.

“We be terrifically enthralled that we enjoy meet this clinical milestone and can instigate to position human follow-up antagonistic this up-and-coming compound,” said Jack Armstrong, President and Chief Executive Officer of Genaera. “What we swot uphill here most primitive chapter of clinical carrying out tests will sustain us attain how MSI-1436 bring about in the human article and escort the willpower of an optimal energizing dose in adoption of the larger efficacy audition which tail. The helpfulness and part of this industry will be necessary benchmarks for Genaera exciting readdress.” About Trodusquemine (MSI-1436) Trodusquemine is a centrally and peripherally-acting appetite suppressant and the first importantly selective inhibitor of protein tyrosine phosphatase 1B (PTP-1B). PTP-1B is milieu to controlling the manoeuvre of both the leptin and insulin pathway. By inhibit PTP-1B, MSI-1436 is expected to drop appetite and normalize blood sugar. Trodusquemine has produced unvarying, sustainable freight annihilation in a tipple of animal model and come into view to prevail metabolic readjustment, which widely borders chronic weight loss during caloric expurgation. In knick-knack, trodusquemine has shown the potential to reverse co-morbidities associated near obesity such by the use of unusual glucose metabolism and cholesterol elevation.

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